The endocannabinoid system (ECS) is a group of cannabinoid receptors located in the brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. There are two main types of receptors in the ECS, CB1 and CB2. CB1 receptors are primarily located in the central nervous system and brains of mammals, and CB2 are generally found in the peripheral nervous system. There are two main cannabinoids mammals produce- 2AG and Anandamide. Read more by clicking here

With no regulations when it comes to the distribution of CBD hemp-based products, you can never be sure what you are purchasing. This leaves consumers exposed to the side effects of impure hemp oil CBD. Despite these challenges, it is possible to buy the right CBD oil in the market. Several reputable companies have risen to offer reliable, safe and potent CBD products to the market. Read reviews of the top selling CBD oils on our site to get an understanding of what makes them unique in this rapidly growing market so you can make an informed decision. Our goal is to bring CBD to the people while helping them make better decisions every day. You can count on us to provide CBD reviews you can trust. Keep in mind that we recommend only the best CBD brands on the market.


Although there’s a very long list of published studies of benefits, these are some of the most common uses of coconut oil: kills bacteria, fungi, yeast, and viruses, improves digestion and absorption of other vitamins and minerals, adds shine to hair and the reduction of protein loss in damaged hair, perfect massage oil due to its moisturizing properties, it increases the body’s metabolic rate which aids in weight loss and gives a boost of energy, it’s also used as an antifungal, antibacterial and antiviral, which strengthens the immune system.
Industrial hemp has low THC levels compared to marijuana specifically cultivated for personal psychoactive use. Whereas marijuana that can be smoked usually contains between five and ten percent THC, industrial hemp contains about one-tenth of that. In order to get a psychoactive effect, one would need to smoke ten or twelve hemp cigarettes over a very short period of time.
In fact, numerous studies have looked at the relationship between CBD and pain, and the results are promising. Researchers have looked at various kinds of pain – from joint pain to cancer pain. One finding is that CBD increases levels of glutamate and serotonin – both neurotransmitters that play a role in pain regulation. And CBD’s anti-inflammatory properties help by tackling the root cause of much chronic pain.
However, at this point, research is still needed, and the surest way to avoid scams is to beware of those products that claim to cure everything. Maybe they do have beneficial properties, but playing with people’s minds and hearts and with their desperate need to find a reliable treatment for painful conditions is not the right way to promote a product.
Disclosure: Some of the links above are affiliate links, meaning, at no additional cost to you, we will earn a commission if you click through and make a purchase. We are a professional review site that may receive compensation from certain companies whose products we review. We test each product thoroughly and give high marks to only the very best. We are independently owned and the opinions expressed here are our own.
Dixie Botanicals® is one of the most recognizable CBD brands in the world, offering full-spectrum CBD hemp oil to thousands of customers in over 40 countries, including the entire U.S. Featuring convenient, consumer-focused products that make taking CBD supplements a snap, even on the go, the Dixie Botanicals® lifestyle brand has become synonymous with high quality CBD hemp oil in the minds of our customers, and we can do the same for you.
Trust isn’t given. It’s earned. And our commitment to safety is a reason we have become the trusted source of CBD for over 100,000 customers. Our hemp is grown free from chemical fertilizers, pesticides, and herbicides. This helps to ensure that no residual contaminants make it into our final products. We take this passion for safety a step further than other hemp oil products by putting our products through a Triple Lab Tested™ process that checks our oil from start to finish for contaminants like mold, mildew, fungus, yeast, E.coli, Salmonella, Mycotoxins, and heavy metals.
If you have a nervous or misbehaving pet, you may be at a loss when it comes to how to help them. Anxiety in dogs can be extremely hard to treat — after all, it’s not like you can have a conversation with your dog to find out what is wrong or how you might be able to help. However, you may have seen CBD making headlines as of late. What is CBD used for when it comes to pets? The answer may surprise you!
Finally, in a 2016 review conducted by oncologist Dr. Donald Abrams studying cannabis’ role in cancer care, the authors state, “preclinical data suggest that cannabinoids could have direct antitumor activity, possibly most impressive in central nervous system malignancies. Clinical data about the effects of cannabis concentrates on cancer are as yet unavailable. Oncologists could find cannabis and cannabinoids to be effective tools in their care of patients living with and beyond cancer”. The review also notes that 82 percent of oncologists believe their cancer patients should have legal access to cannabis, according to a 2014 WebMD poll.
For those needing a refresh, CBD or cannabidiol is one of the many compounds, or cannabinoids, found both in cannabis sativa (federally illegal) and industrial hemp (gray area) that has shown preclinical promise in treating anxiety and inflammation. Adding to its therapeutic legitimacy, CBD was recently FDA-approved to be used in an epilepsy drug called Epidiolex making it the first cannabis compound to be federally recognized. Over the last year, CBD’s become the darling of the wellness world, working its way into our juices, facials, creams, and cocktails, purportedly giving people the benefits of cannabis without the THC high. Very chill.

Real Scientific Hemp Oil™ is the world’s leading hemp CBD oil brand. All RSHO™ products are derived from non-GMO hemp, scientifically extracted using a solvent-free CO2 process, and quality-certified through our Triple Lab Testing™ process to bring the powerful natural benefits of hemp CBD. It’s a science that we take great pride in day in and day out.


Every CBD product should make third-party lab results available, either online, in their packaging, or by request. At minimum, each tincture here offers lab results showing the levels of cannabinoids like CBD and THC, while others offer additional tests. The more information available to consumers the better. At the same time, we admit it isn’t always easy for newcomers to interpret these lab tests.

The Cibaderm® line of all-natural CBD-based beauty and bath products features our proprietary Hemp CBD™ Complex to integrate the benefits of hemp into your bath routine. Cibaderm® products are formulated without dyes or scents and are sulfate and paraben-free. Each product in the Cibaderm® bath line contains steam-distilled botanical ingredients, like ginseng, white peony, goji berry, white mulberry leaf, licorice root, and almond oil, specifically chosen to clean, condition, and moisturize your skin and hair. To these herbal extracts, Cibaderm® adds sustainable CBD hemp oil for healthy, beautiful looking skin and hair.
For those customers looking to balance cost and potency, three of our popular brands, RSHO™, Dixie Botanicals®, and Cibdex®, carry a line of CBD hemp oil capsules with a moderate 25 mg of CBD per capsule. These medium potency capsules contain the same CBD hemp oil as our other products, making it simple to take your CBD supplements with you. These bottles fit easily into an overnight bag or briefcase and are never out of place in a bathroom medicine cabinet or office drawer, ensuring your CBD hemp oil supplements are within reach.
The human body has an endocannabinoid system — a natural system that maintains homeostasis or balance, in the body. The endocannabinoid system has CB1 and CB2 receptors. These are found throughout the body. CB1 receptors are generally located in the central and peripheral nervous system and CB2 receptors are generally found in the brain, immune system, and gastrointestinal system. CBD binds to these receptors creating changes and effects in the body
CBD hemp oil supplements are taken to promote homeostasis within the body. Why tamper with this balance by choosing a supplement loaded with artificial ingredients? HempMeds® uses all-natural ingredients in all our CBD hemp oil products for a pure, healthful dietary supplement. These ingredients include botanical extracts like peppermint oil and almond oil and sustainable beeswax, coconut oil, and ginger root. Our commitment to high-quality, natural ingredients promotes well-being and preserves the balance our products were designed to create. Here are some more details about the natural ingredients we use:
Also, out of the 50 U.S states, 29 states permit in some way or another the use of medical weed, which includes cannabis CBD oil for specific treatments. So where is the problem? Qualifying for a medical card is the easy part, but the problem is going through long, tiring bureaucratic BS processes with the state’s Board of Health, to try to obtain one.
Real Scientific Hemp Oil™ is the world’s leading hemp CBD oil brand. All RSHO™ products are derived from non-GMO hemp, scientifically extracted using a solvent-free CO2 process, and quality-certified through our Triple Lab Testing™ process to bring the powerful natural benefits of hemp CBD. It’s a science that we take great pride in day in and day out.

Been using CBD for the past 2 years. I’ve tried quite a few of them. There are only a handful of reputable brands on the market like CW, Purekana and a few others. I can’t remember their names. I recently tried the fourth one on this list, premiumjane. Good stuff and helps with the pain I get in my shoulder. Would recommend it for acute pain. I am not sure if it would work for more serious problems. Anyone else?
What’s more, CBD vape oils require additional equipment. In order to transform the oil into vapor, you’ll need an e-pen or vaporizer. This means an extra investment on top of the vape oil itself. I therefore recommend that, if you’re a first-time user, you try a more accessible and affordable CBD product type to make sure it’s the right supplement for you, before graduating to vape oil.

Cristina Sanchez, a molecular biologist from Complutense University in Madrid, Spain, explains to CannaInsider, “cells, not only cancer cells, but every cell in our body can die in different ways. One could be similar to an accident, a car accident, a traumatic death which is called necrosis. And there is another way to die which is a clean death and by clean I mean no inflammation of the surrounding tissues. And this cancer cell death is called Apoptosis. And when someone’s dealing with anti-tumor compounds, one wants this particular kind of death to happen because the other one is associated to inflammatory processes and things like that that you don’t want in a patient.”
* All CBD products offered on this site are produced in compliance with 21 U.S.C. § 802(16), 21 CFR 1308.11(d)(58 – 7350 Marijuana Extract),  and “Clarification of the New Drug Code (7350) for Marijuana Extract” published by the US Department of Justice, Drug Enforcement Administration, Diversion Control Division https://www.deadiversion.usdoj.gov/schedules/marijuana/m_extract_7350.html
I have my MMC but don’t care for the Trustik Pod 800mg Sativa for use with my vape pen. I don’t like the high feeling, plus need to be able to drive to my doctors appts. I want to try CBD again. Had tried Charlotte’s Web by Stanley Brothers of Colorado and it helped a little but not enough to stop narcotics I am on. Would the CBD products from dispensary be stronger than what I tried before?
The cannabis plant has been at the center of worldwide controversy in recent years, as restrictive cannabis policies are starting to shift toward more compassionate medical and recreational use laws. This patchwork of change, however, has created a confusing and often contradicting set of cannabis policies, making it difficult to know exactly where you stand when trying to access cannabis where you live. Here we answer some common questions about who can purchase CBD hemp oil products and where.

Dogs and cats are known for their powerful sense of smell. They typically don’t like having something new added to their food, making supplementing their diets to ease health issues challenging. However, CBD products for pets take that challenge into account. Developed by dedicated veterinarians, they’ve been designed to pass the taste and smell test.
It depends on the testing standards of the lab administering your drug test. Most companies only search for the cannabinoid THC, which is the main psychoactive component of the marijuana plant. While Medterra products are THC free, there are some testing facilities that check for a spectrum of cannabinoids and could trigger a positive drug test. By law, you are allowed to ask the facility what cannabinoids they test for. If you are uncomfortable with that, you can call and ask anonymously. We suggest contacting the testing facility if there is any concern.

We also rated the product based on the type of CBD they used: isolate, full-spectrum decarb, broad-spectrum, or distillate. There’s a lot of debate around what is actually best, but our first decision was to give points to CBD oil that contains a range of cannabinoids. While there are certainly people with good reasons for choosing an isolate, there’s a lot of good evidence that CBD works better in combination with other cannabinoids (this is called the “entourage effect”).
There are over 85 cannabinoids that make up the marijuana plant. The most popular and well known of these is tetrahydrocannabinol, or better known as THC. THC is a psychotropic cannabinoid that causes a high when inhaled or ingested. CBD has no THC. This means those dealing with various forms of pain and depression can safely use CBD to curb negative effects on the body without having to turn to prescription pharmaceuticals.
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
To determine the purity and potency of every batch of Hemp cannabis oil each individual extraction is analyzed through a High Pressure Liquid Chromatography (HPLC) system, a Gas Chromatography-Mass Spectrometry (GC-MS) system, and other methods to test for aerobic organisms, yeast, fungus, E. coli, pesticides, heavy toxic metals, cannabinoid potency, and terpenes.
Both the National Cancer Institute and the American Cancer Society recognize the potential of CBD oil in suppressing and fighting the spread of life-threatening cancer cells. Although they claim that CBD can’t be a cure, a growing number of studies suggest that cannabidiol can help to suppress the development and progression of various cancers, such as lung, breast, colon, and prostate cancers.
There is a lot to be hopeful for as legalization marches forward and as cannabis becomes more widely accepted for its medicinal purposes. Unfortunately, with cannabis and CBD still listed as schedule one substances, research is limited and many medical professionals still remain in fear to discuss or endorse medical cannabis for something like cancer. As of March 2015, over 15,000 patients in the state of Colorado reported severe nausea or cancer as their reporting condition for their medical card. Organizations like Project CBD, Realm of Caring, and CannaKids provide resources and connect families who seek cannabinoid therapy for their illnesses. According to a 2016 estimate by procon.org, there are over 2.5 million medical marijuana users in the United States. This number grows every year as more states legalize access to medical cannabis and it’s becoming harder for the mainstream medical community to ignore this growing group of people.

Once companies have these test results, sharing them with customers is not just a best practice—it should be a priority. After all, you shouldn’t have to guess what’s in the bottle or wait to read results until a product arrives in your mailbox. That, says Diamond CBD, is why their team makes test results for CBD oils and tinctures available online, right next to the product description.
So in regard to hemp CBD oil I bet you are thinking, “it’s less effective.” Well, let’s put a few things into perspective. First, it is certainly not going to blow you away and give you a buzzin’ high. In fact, it’s widely known that hemp-based CBD oil produces no psychoactive response whatsoever. Furthermore, it isn’t going to cure cancer, or “cure” any disease for that matter. It may, however, help with mild conditions such as pain, anxiety, and arthritis – if dosed correctly, in consultation with your doctor. Similar to most things in life, it is a matter of what works best for you; there are currently hundreds of CBD Oil brands on the market, and what might work for one person, might not work at all for another. The question is finding what works for you and if you do find it, it just might change your life around from head to toe.
Sanchez explains further, “chemotherapy attacks every single cell in our body that is undergoing proliferation. Every cell that is dividing will be attacked by chemotherapy. And which cells are dividing in our body? First cancer cells of course, those are the ones you want to kill, but also the cells of your immune system, the cells of your stomach and a lot of tissues. So that’s why chemotherapy is so toxic because it’s not only attacking cancer cells but other cells that are proliferating inside our bodies. And the difference with cannabinoids is that these compounds only attacked cancer cells. We don’t understand why yet in molecular terms. We don’t know what makes a cancer cell different in terms of the sensitivity to cannabinoids, but we know that this is a fact. Cannabinoids kills cancer cells and they do not affect the viability of non-cancer cells.”
Good morning! I’ve been researching CBD oil for a couple of years and I’ve tried a few CBD oils. I am very satisfied with the one I am presently taking which meets all of the requirements stated, organically grown in the US, laboratory tested for quality etc . If anyone would like more information I’d be happy to help. Just shoot me an email at [email protected] I’m a firm believer in the benefits of CBD oil and finally found one that works for me!
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