While THC affects your brain’s endocannabinoid receptors (resulting in the high), CBD does not attach directly to the receptors. Instead, it influences your body into using its own natural supply of cannabinoids more effectively. That is to say, it can inhibit or activate compounds in the ECS, which in turn can impact the amount of pain you feel or limit inflammation in the brain and nervous system.

CO2 extraction is one of the most common ways CBD is extracted from the hemp or cannabis plants. This method uses expensive equipment that adjusts temperature and pressure to extract the cannabinoids from the plant material, without damaging them. The other common method is to use solvents like ethanol or butane to extract the plant material. These solvents have to be burned off the final product which may damage the cannabinoids or terpenes in the process. There is also a risk that these solvents may not have burned off completely and could end up in your end product.
In fact, numerous studies have looked at the relationship between CBD and pain, and the results are promising. Researchers have looked at various kinds of pain – from joint pain to cancer pain. One finding is that CBD increases levels of glutamate and serotonin – both neurotransmitters that play a role in pain regulation. And CBD’s anti-inflammatory properties help by tackling the root cause of much chronic pain.
CBD may be best known for its relaxing, calming effects. CBD reduces autonomic arousal, having the inverse effect of THC on the body. CBD’s anti-anxiety effect is why many in the cannabis community talk about how CBD relieves paranoia, although that is not scientifically proven yet. CBD is also known for its anti-nausea and pain relieving effects. It really depends on why your body’s specific needs and the quantity in which you take CBD.
So, back to the difference between how effective hemp extract is compared to marijuana extract.  It is the subtle mixture of how much CBD and how much THC and how much of the other cannabinoids that can change the effectiveness for people.  For most of us, we won’t notice much difference in the subtle variations, other than the extract from marijuana will make you high, while the extract from hemp won’t.  However, there is a very small percentage of people whose bodies can tell the difference.  Some people find that they get better results when using an extract high in THC.  And, some people find that they get better results when using an extract that is low in THC.  This just comes down to these people’s bodies; and again, the percentage of these type of people is very low.
Strength is also an extremely important consideration. Beginners may find that it’s easier to control dosage using a lower strength tincture. On the other hand, experienced CBD consumers know that high strength tinctures are more cost effective. Although stronger tinctures cost more, you get more CBD oil and other beneficial cannabinoids in each drop. Most CBD brands offer more than one option for strength.
As of now, there are only 9 states (and Washington, D.C.) that permit the use of marijuana on a recreational level. This means that, depending on where you live, it may or may not be possible to just walk into a dispensary and ask for a bottle of fine quality CBD oil. Also, some of those 9 states (even though they are recreationally legal for weed) may actually require you to obtain a medical marijuana card or a physician’s recommendation for CBD oil. If this is the case, though, it’s really no biggy as getting an online recommendation is incredibly easy nowadays, and can usually be done in minutes..
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
But, and there’s always a “but” when it comes to weed in America, unless you’re buying cannabis CBD in a state where weed is recreationally legal or have a medical card in a legalized state, you’re shopping in the unregulated market that is industrial hemp CBD. (Full disclosure: I've worked with restaurants to launch hemp-CBD drinks and am the co-founder of Nice Paper, a site about cannabis.)
The range of qualified medical conditions that Marijuana’s cannabinoids help treat, the main being THC and CBD are growing daily. A few of these include MS, seizures, eating disorders, HIV and cancer. Cannabis is also a treatment for mental health issues such as PTSD that many of our proud Texas Veterans are dealing with today. One Texas Veteran said when asked if medical marijuana helped his PTSD, the reply was “Weed is a miracle for PTSD, sometimes I think I smoke a lot, then it occurred to me that I haven’t wanted to hit anyone in 6 months.”
CBD isolate will not show up on any drug test because it’s not made from the whole plant; traces of THC are within the legal limit & individual states are now passing laws to protect employees who are medical marijuana patients. It’s changing constantly & many states have patient advocacy groups that help new patients navigate the big learning curve.

Finally, in general, we almost always recommend full spectrum tinctures over supplements made from isolates (extracts of CBD alone). Full-spectrum or whole plant tinctures take advantage of the ‘entourage effect’ that comes from combining all the naturally occurring chemicals found in the hemp plant. Isolates are great for cooking with CBD or consumers that are especially sensitive to the taste of hemp extract, but some research suggests they may be less effective for certain uses than full spectrum extracts. All but two of the brands below are made from full spectrum hemp, and the exceptions are clearly noted.
In fact, numerous studies have looked at the relationship between CBD and pain, and the results are promising. Researchers have looked at various kinds of pain – from joint pain to cancer pain. One finding is that CBD increases levels of glutamate and serotonin – both neurotransmitters that play a role in pain regulation. And CBD’s anti-inflammatory properties help by tackling the root cause of much chronic pain.
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
Industrial hemp has low THC levels compared to marijuana specifically cultivated for personal psychoactive use. Whereas marijuana that can be smoked usually contains between five and ten percent THC, industrial hemp contains about one-tenth of that. In order to get a psychoactive effect, one would need to smoke ten or twelve hemp cigarettes over a very short period of time.
It was a tough choice, but if you are anxious to order quality CBD oil online and want it delivered as fast as possible, then check out PureKana. Apart from investing a huge amount of resources into customer support, it truly feels as if the team at PureKana really cares about delivering high-quality CBD therapy to suffering individuals all across the country.
“The need for enhanced bioavailability of the CBD phytonutrient is paramount”, adds Moriarity, “but tricky to accomplish without synthetic chemicals.” Most CBD products do not offer any bioavailability optimization, so 90 percent of the CBD is lost to first-pass effect, a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches systemic circulation.
I am in a pain management program and I was told that they test for cannabiniols across the board so even though there is no THC I could still test positive and be kicked out of the program. This is so unfair because CBC has been the best thing for PTSD anxiety and depression instead they would rather me be on multiple drugs with multiple bad side effects. Even though it’s legal in KY we re still in the dack ages. Any thoughts or help on this I would greatly appreciate how to get around it.
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